辛伐他汀对急性冠脉综合征患者血清MMP-9及sICAM-1的影响

被引:2
作者
张承俊 [1 ]
朱兴雷 [2 ]
机构
[1] 山东省济南市第一人民医院内科
[2] 山东省立医院
关键词
斯伐他汀; 冠状动脉疾病; 明胶酶B; 胞间粘附分子1;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
目的探讨辛伐他汀对急性冠脉综合征(ACS)患者MMP-9和ICAM-1的影响。方法检测96例ACS患者MMP-9、ICAM-1和CPR,并进行治疗前后的比较。结果急性心梗(AM I)和不稳定性心绞痛(UA)经辛伐他汀治疗4周后均明显下降。结论辛伐他汀有减轻炎症反应及心血管保护的作用。
引用
收藏
页码:707 / 708
页数:2
相关论文
共 5 条
[1]  
Antiatherothrombotic properties of statins:im-plications for card iovascu lar event reduction. Rosenson RS,Tangney CC. The Journal of The American Medical Association . 1998
[2]  
Expression of matrixm etallo-proteinase-9 and its inh ib itors in mononuclear b lood cells of patients w ithatherosclerosis. L ichtinghagen R,Seifert T,Kracke A,et al. C ircu lation . 2000
[3]  
D ifferential expression ofmatrixm et-alloproteinases in card iovascu lar d iseases. K ieseier BC,Pau l R,KoedelU,et al. B rain . 2002
[4]  
Inh ib ition of alpha4 integrinand ICAM-1 marked ly attenuate macrophage to atheroselerotic plaques inApoE-deficientm ice. Patel SS,Th iagarajan R,W illerson JT,et al. C ircu lation . 1999
[5]  
Experim entalm etastasisis suppressedin MMP-9-deficientm ice. Itoh T,Tan iokaM,Matsuda H,et al. C lin Exp M etastasis . 1999