五环三萜皂苷的药理作用研究进展

被引:57
作者
程晓华
熊玉卿
机构
[1] 南昌大学医学院临床药理研究所
关键词
五环三萜皂苷; 抗肿瘤; 抗炎;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
1008 ;
摘要
五环三萜皂苷是天然产物中重要的成分之一,大多具有广泛的药理活性,临床应用前景十分诱人。随着五环三萜皂苷研究的不断深入,对其药理学作用机制的阐明和新药研发已成为此类化合物研究的热点之一。就国内外学者对五环三萜皂苷抗肿瘤、护肝、抗炎、以及机体免疫调节等药理学作用的研究进展做一综述。
引用
收藏
页码:792 / 795
页数:4
相关论文
共 15 条
[1]   Lupeol and its ester ameliorate the cyclophosphamide provoked cardiac lysosomal damage studied in rat [J].
Periyasamy Thandavan Sudharsan ;
Yenjerla Mythili ;
Elangovan Selvakumar ;
Palaninathan Varalakshmi .
Molecular and Cellular Biochemistry, 2006, 282 :23-29
[2]  
Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in ‘orujo’ olive oil, on rat aorta[J] . Rosalía Rodríguez-Rodríguez,María Dolores Herrera,Javier S. Perona,Valentina Ruiz-Gutiérrez.British Journal of Nutrition . 2004 (4)
[3]  
Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells[J] . Ya-Ling Hsu,Po-Lin Kuo,Chun-Ching Lin.Life Sciences . 2004 (19)
[4]   Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes [J].
Kim, KA ;
Lee, JS ;
Park, HJ ;
Kim, JW ;
Kim, CJ ;
Shim, IS ;
Kim, NJ ;
Han, SM ;
Lim, S .
LIFE SCIENCES, 2004, 74 (22) :2769-2779
[5]  
Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line[J] . Wing-Keung Liu,Joyce C.K. Ho,Florence W.K. Cheung,Bonnie P.L. Liu,Wen-Cai Ye,Chun-Tao Che.European Journal of Pharmacology . 2004 (1)
[6]   Effects of ursolic acid on different steps of the angiogenic process [J].
Cárdenas, C ;
Quesada, AR ;
Medina, MA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 320 (02) :402-408
[7]   Ursolic acid protects hippocampal neurons, against kainate-induced excitotoxicity in rats [J].
Shih, YH ;
Chein, YC ;
Wang, JY ;
Fu, YS .
NEUROSCIENCE LETTERS, 2004, 362 (02) :136-140
[8]  
Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system[J] . T.J. Raphael,G. Kuttan.Phytomedicine . 2003 (6)
[9]  
Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension[J] . L.O. Somova,A. Nadar,P. Rammanan,F.O. Shode.Phytomedicine . 2003 (2)
[10]  
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus[J] . J Cinatl,B Morgenstern,G Bauer,P Chandra,H Rabenau,HW Doerr.The Lancet . 2003 (9374)