干预Hhcy、高血压病对高血压病合并Hhcy脑梗死复发的影响

被引：7

作者：

刘海艳

魏秀娥

荣良群

机构：

[1] 徐州医学院第二附属医院神经内科

来源：

卒中与神经疾病 | 2014年 / 21卷 / 02期

关键词：

高同型半胱氨酸血症; 高血压病; 脑梗死; 复发;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）]; R544.1 [高血压];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨干预高血压病、高同型半胱氨酸血症对高血压病合并Hhcy脑梗死复发的影响。方法采用前瞻平行对照法将300例高血压病合并Hhcy脑梗死分为A组150例,依那普利叶酸+常规治疗(依那普利叶酸10 mg∶0.8 mg/d),每日1次;B组150例:常规治疗(不含B族维生素)。随访2年观察联合干预高血压病、Hhcy对高血压病合并Hhcy脑梗死复发的影响。结果在6、12、24个月随访期间依那普利、叶酸+常规治疗组(A组)Hcy水平显著低于常规治疗组(B组)(P<0.05),血压水平2组无明显的差异(P>0.05);依那普利、叶酸+常规治疗组(A组)脑梗死复发率为15.15%;常规治疗组复发率为17.85%,2组间差异明显(P<0.05)。Logistic回归分析显示HCy降低、血压下降是高血压病合并Hhcy脑梗死复发的保护性因素,OR值分别为0.665、0.542。结论同时控制高血压病、Hhcy可降低高血压病合并Hhcy脑梗死的复发。

引用

页码：72 / 74+77 +77

页数：4

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