心肌营养素-1在大鼠缺血再灌注心肌中的表达及神经调节蛋白-1对其表达的促进作用

被引：2

作者：

陈辉 ^{[1
]}

陆超 ^{[1
]}

邵小松 ^{[1
]}

周艳 ^{[1
]}

吴升华 ^{[1
]}

孔祥清 ^{[2
]}

机构：

[1] 南京医科大学第一附属医院儿科

[2] 南京医科大学第一附属医院心内科

来源：

实用儿科临床杂志 | 2006年 / 01期

关键词：

心肌营养素-1; 缺血; 再灌注; 神经调节蛋白-1; 大鼠;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

目的研究大鼠缺血再灌注心肌中心肌营养素-1(CT-1)的表达及神经调节蛋白-1(NRG-1)对其表达的影响。方法制备大鼠缺血再灌注心肌模型,分为模型组(n=8),NRG-1预处理组(n=9),假手术组(n=8)和正常对照组(n=10)。利用RT-PCR技术检测各组CT-1 mRNA表达,计算CT-1 mRNA相对量,并作统计学处理。结果模型组CT-1 mRNA结果(63.96±9.34)高于假手术组(36.16±5.43)和正常对照组(36.84±4.64),三者比较差异有显著性(F=47.37 P<0.01);NRG-1预处理组(89.49±6.99)高于模型组,差异有显著性(t=6.43 P<0.01)。结论大鼠心肌缺血再灌注后CT-1 mRNA表达升高,其原因可能是缺血再灌注激活机体内源性保护机制,NRG-1预处理对心肌的保护作用可能与提高心肌细胞中CT-1的表达有关。实用儿科临床杂志,2006,21(1):29

引用

页码：29+52 / 29 +52

页数：2

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