高糖诱发氧化应激导致血管内皮细胞凋亡机制研究

被引：13

作者：

任蓓

潘澄

林鹏

吴斐华

马世平

机构：

[1] 中国药科大学中药药理教研室

来源：

海峡药学 | 2013年 / 25卷 / 06期

关键词：

高糖; 血管内皮细胞; 细胞凋亡; 糖尿病;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

糖尿病是一组由于遗传因素和环境因素共同作用而导致的临床综合征,其血管并发症是导致糖尿病患者致死和致残的主要原因。血管内皮细胞凋亡在糖尿病血管并发症的发生发展过程中起重要作用。高糖能诱发氧化应激,通过一系列复杂的信号通路,如NF-κB信号通路、JNK信号通路、PI3K/AKT信号通路等直接或间接引起血管内皮细胞凋亡。改善高糖诱导的细胞凋亡可能成为治疗糖尿病及其各种并发症的一种有效途径。

引用

页码：268 / 271

页数：4

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