瑞舒伐他汀后处理通过抑制高迁移率族蛋白表达减轻心肌缺血再灌注损伤的研究

被引：7

作者：

胡晶晶

陈小云

周伟

刘福兴

机构：

[1] 湖北省钟祥市人民医院心内科

来源：

贵州医药 | 2016年 / 40卷 / 08期

关键词：

瑞舒伐他汀; 高迁移率族蛋白; 心肌缺血再灌注损伤;

D O I：

暂无

中图分类号：

R542.2 [心肌疾病];

学科分类号：

100201 [内科学];

摘要：

目的研究瑞舒伐他汀(RS)后处理是否可以通过抑制高迁移率族蛋白(HMGB1)的表达减轻心肌缺血再灌注损伤(I/R)。方法使用SD大鼠缺血再灌注模型,缺血30min,再灌4h。将大鼠随机分为假手术组(n=10)、缺血再灌注组(n=15)和RS后处理组(n=15)三组,检测血清中乳酸脱氢酶(LDH)水平和肌酸激酶(CK)活性、心肌组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平及心肌梗死面积和心肌中HMGB1的表达水平。结果 RS后处理能明显减少梗死面积(P<0.05)及LDH、CK活性(P均<0.05);明显抑制MDA的升高和SOD的活性(P均<0.05);明显抑制HMGB1的表达(P<0.05)。结论 RS后处理对心肌I/R的保护作用与抑制HMGB1的表达有关。

引用

页码：798 / 800

页数：3

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