MPTP和帕金森病研究新进展

[1] A primate model of Parkinsonism: selective destruction of substantia nigra pars compacta dopaminergic neurons by N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Burns RS,et al. Proceedings of the National Academy of Sciences of the United States of America . 1983

[2] Protection against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid. Sershan H,et al. Neuropharmacology . 1985

[3] Effect of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on age-related changes in dopamine turnover and transporter function in the mouse striatum. Sershan H,et al. European Journal of Pharmacology . 1985

[4] Parkinson’s disease: An environmental cause. Lewin R,et al. Science . 1985

[5] Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2, 3, 6-tetrahydropyridine:Uptake of the metabolite N-methyl-4-phenyl pyridine by dopamine neurons explains selective toxicity. Javitch JA,et al. Proceedings of the National Academy of Sciences of the United States of America . 1985

[6] The protective effect of 1-tert.Butyl-4,4-diphenylpiperidine against the nigrostriatal neurodegeneration caused by l-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine. Przuntek H,et al. Life Sciences . 1985

[7] MPTP: A neurotoxin relevant to the pathophysiology of Parkinson’s disease. Snyder SH,et al. Neurology . 1986

[8] MPTP and Parkinson’s disease. Langston JW. Trends in Neurosciences . 1985

[9] MPTP-induced Parkinsonism in human and nonhuman primates-clinical and experimental aspects. Langston JW,et al. Acta Neurologica Scandinavica . 1984

[10] Partial protection from the dopaminergic neurotoxin N-methy-1-4-phenyl-1, 2, 3, 6-tetrahydropyridine by four different antioxidants in the mouse. Perry TL,et al. Neuroscience Letters . 1985

[1] A primate model of Parkinsonism: selective destruction of substantia nigra pars compacta dopaminergic neurons by N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Burns RS,et al. Proceedings of the National Academy of Sciences of the United States of America . 1983

[2] Protection against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid. Sershan H,et al. Neuropharmacology . 1985

[3] Effect of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on age-related changes in dopamine turnover and transporter function in the mouse striatum. Sershan H,et al. European Journal of Pharmacology . 1985

[4] Parkinson’s disease: An environmental cause. Lewin R,et al. Science . 1985

[5] Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2, 3, 6-tetrahydropyridine:Uptake of the metabolite N-methyl-4-phenyl pyridine by dopamine neurons explains selective toxicity. Javitch JA,et al. Proceedings of the National Academy of Sciences of the United States of America . 1985

[6] The protective effect of 1-tert.Butyl-4,4-diphenylpiperidine against the nigrostriatal neurodegeneration caused by l-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine. Przuntek H,et al. Life Sciences . 1985

[7] MPTP: A neurotoxin relevant to the pathophysiology of Parkinson’s disease. Snyder SH,et al. Neurology . 1986

[8] MPTP and Parkinson’s disease. Langston JW. Trends in Neurosciences . 1985

[9] MPTP-induced Parkinsonism in human and nonhuman primates-clinical and experimental aspects. Langston JW,et al. Acta Neurologica Scandinavica . 1984

[10] Partial protection from the dopaminergic neurotoxin N-methy-1-4-phenyl-1, 2, 3, 6-tetrahydropyridine by four different antioxidants in the mouse. Perry TL,et al. Neuroscience Letters . 1985