姜黄素对脓毒症大鼠肾组织ICAM-1表达和MPO活性的影响

被引：2

作者：

夏炎火 ^{[1
]}

姚华国 ^{[2
]}

邵义明 ^{[2
]}

张媛莉 ^{[2
]}

冼海涛 ^{[2
]}

机构：

[1] 温州医学院附属第一医院ICU

[2] 广东医学院附属医院ICU

来源：

海峡药学 | 2008年 / 09期

关键词：

姜黄素; 脓毒症; 细胞间粘附分子-1; 肾组织; 中性粒细胞;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

目的观察姜黄素对脓毒症大鼠肾组织ICAM-1mRNA表达、MPO活性的影响,探讨其保护肾功能的可能机制。方法90只SPF级SD大鼠随机分为假手术组(Sham组)、盲肠结扎穿孔组(CLP组)、姜黄素治疗组(Cur组),CLP组和Cur组进行盲肠结扎穿孔术,Cur组予姜黄素液2mL.kg-1(即100mg.kg-1)腹腔注射,Sham组、CLP组给予2mL.kg-1生理盐水腹腔注射。各组大鼠于术后0、3、6、12、24、48h活杀动物取材,观察姜黄素处理后大鼠肾组织ICAM-1mRNA表达、髓过氧化物酶(MPO)活性及血清尿素氮(BUN)、肌酐(Scr)的变化。结果CLP术6h后Cur组肾组织ICAM-1mRNA表达、MPO活性明显低于CLP组(P<0.05),术后48h血清BUN、Scr水平亦明显低于CLP组(P<0.05)。结论姜黄素对脓毒症大鼠肾损伤的保护作用可能与其抑制ICAM-1表达,减少过量中性粒细胞在肾组织中聚集有关。

引用

页码：31 / 34

页数：4

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