BDNF在抑郁症发病机制中的作用及其抗抑郁作用机制的研究进展

被引：26

作者：

董爱国 ^{[1
]}

赵丽丽 ^{[1
]}

李海红 ^{[2
]}

机构：

[1] 汕头大学精神卫生中心

[2] 汕头大学医学院第二附属医院

来源：

中国医疗前沿 | 2011年 / 6卷 / 06期

关键词：

BDNF; 抗抑郁药; 抑郁症;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

摘要：

BDNF是一种内源性蛋白质,广泛存在于人类的大脑及外周神经系统。其主要来源于血小板、大脑神经元和血管内皮细胞,大多数的BDNF蛋白储存在血小板中。它在维持中枢及外周神经元可塑性、存活、分化等方面起到重要的作用,其表达是否正常可能与抑郁症的发病机制有关。抗抑郁药物对BDNF水平的调节可能与其抗抑郁机制之间有交叉点。

引用

页码：16 / 18+87 +87

页数：4

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