中国和美国部分人群瘦体重与初潮年龄单变量GWAS分析鉴定出KCNA基因附视频

被引：6

作者：

海荣 ^{[1
]}

张垒 ^{[2
]}

高学文 ^{[1
]}

机构：

[1] 内蒙古自治区人民医院干部保健所

[2] 上海理工大学

来源：

中华保健医学杂志 | 2015年 / 02期

关键词：

单变量全基因组关联研究; 初潮年龄; 瘦体重; KCNA基因;

D O I：

暂无

中图分类号：

R746 [神经肌肉疾病];

学科分类号：

100204 [神经病学];

摘要：

目的探讨少肌症主要表型瘦体重(lean body mass,LBM)和初潮年龄(age at menarche,AAM)潜在的多微效基因。方法选择白种人女性1692名作为研究样本,选择中国女性801名作为验证样本。采用Affymetrix公司的Genome-Wide Human SNP Array 6.0芯片套装,对研究样本和验证样本的909622单核苷酸多态性(single Nucleotide Polymorphism,SNP)进行基因分型,然后对四肢LBM和AAM进行单变量全基因组关联分析。结果研究发现单变量全基因组关联研究(genome wide association study,GWAS)鉴定的SNP rs1860547和rs11030746全基因组水平非常显著,经过验证P值小于0.05,在SNP rs1860547上游发现对LBM具有重要影响的KCNA1和KCNA5基因,在SNP rs11030746下游发现KCNA4基因。结论白种人女性中钾电压阀门通道,混合器相关亚家族(KCNA)1、KCNA4、KCNA5基因可能是与LBM密切相关的多微效基因。

引用

页码：104 / 107

页数：4

共 7 条

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