线粒体DNA损伤与视网膜色素上皮细胞关系的研究进展

被引：5

作者：

俞永珍

邹秀兰

邹玉平

机构：

[1] 广州军区广州总医院眼科

[2] 广州医科大学附属第三医院眼科

来源：

天津医药 | 2015年 / 43卷 / 09期

基金：

广东省科技计划;

关键词：

DNA,线粒体; DNA损伤; 视网膜色素类; 上皮细胞; 活性氧; 综述;

D O I：

暂无

中图分类号：

R774.1 [视网膜疾病];

学科分类号：

100212 [眼科学];

摘要：

线粒体DNA(mt DNA)是线粒体内具有遗传效应的双股闭环DNA分子,对细胞及其功能具有重要作用。视网膜色素上皮(RPE)细胞活动亦由大量线粒体参与。因RPE细胞代谢活跃,当发生氧化应激时可引起线粒体及mt DNA损伤;当线粒体及mt DNA损伤无法及时修复而使损伤积累,可引起RPE及线粒体功能障碍,并诱发启动细胞凋亡,进而引发某些眼病,如年龄相关性黄斑变性等。现就mt DNA与RPE细胞的功能关系、mt DNA损伤修复及检测方法作一综述。

引用

收藏

页码：1079 / 1081

页数：3

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