紫外线辐射的尿刊酸对小鼠迟发型超敏反应抑制的研究

被引:5
作者
毕志刚
徐赞
王韬
机构
[1] 南京医科大学第一附属医院皮肤科!邮政编码
[2] 江苏省人民医院临床实验研究室
关键词
尿刊酸; 紫外线; 超敏感性; 迟发型;
D O I
暂无
中图分类号
R965 [实验药理学];
学科分类号
摘要
建立了以小鼠耳厚的增加反映对DNP6-OVA抗原的迟发型超敏反应(DTH)的动物模型,以观察经紫外线辐射的顺式尿刊酸(cis-UCA)对小鼠DTH的抑制程度。结果注射cis-UCA的小鼠耳厚增加与对照组有显著性差异(尸<0.01),而注射反式尿刊酸(trans-UCA)的小鼠耳厚增加与对照无显著性差异(P>0.05)。表明在对DNP6-OVA的免疫应答中,cis-UCA能够抑制细胞免疫反应。
引用
收藏
页码:291 / 293+330
页数:4
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