缺氧缺血性脑损伤细胞凋亡机制的研究进展

被引:4
作者
王来栓
机构
[1] 复旦大学附属儿科医院上海 
关键词
脑缺血; 脑缺氧; 脱噬作用; 婴儿,新生,疾病;
D O I
暂无
中图分类号
R722.121 [];
学科分类号
摘要
缺氧缺血性脑损伤细胞凋亡过程一般经过启动-调控和执行-效应三个阶段。启动阶段的主要事件是一些跨膜信号转导通路的活化和凋亡相关基因的激活;线粒体在凋亡调控和执行阶段起着关键作用;凋亡信号诱使线粒体释放凋亡诱导因子如细胞色素c等,后者又激活半胱天冬酶(caspase)瀑布式级联反应,并激活效应阶段的关键效应酶caspase-3,最终使脑细胞发生不可逆的凋亡。Bcl-2s家族是重要的抗凋亡成员,作用于凋亡途径的不同位点,抑制凋亡的进行。对缺氧缺血性脑损伤细胞凋亡机制的研究,有助于寻找新的抑制或减轻缺氧缺血性脑损伤细胞凋亡的理想途径。
引用
收藏
页码:257 / 260
页数:4
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