抑郁症的成因及其新药治疗研究进展

被引:40
作者
黄良峰
陈洋洋
赵炳功
吴涛
傅正伟
颉孝贤
机构
[1] 浙江工业大学生物工程学院
关键词
抑郁症; 致病机理; 调控因素; 药物治疗; 表观遗传调节;
D O I
10.13241/j.cnki.pmb.2018.01.039
中图分类号
R749.4 [情感性精神病];
学科分类号
100204 [神经病学];
摘要
抑郁症是一种发病率高、危害大的精神疾病,且发病的人群正在急剧增加。抑郁症的成因复杂,其病因机制尚不十分清楚。目前研究的病因主要包括神经递质受体异常、神经退化及内分泌、炎症细胞因子、表观遗传调节和大脑衍生神经营养因子等。随着新病因的揭开,抑郁症治疗的新药及其作用机理研究也取得了较大的进展。研发的新药主要包括:选择性5-羟色胺(5-HT)、去甲肾上腺素(NE)再摄取抑制剂、选择性NE再摄取抑制剂、肾上腺素能和特异性5-HT抗抑郁药、以及新药氯胺酮。本文就抑郁症发病的成因及主要的新药治疗策略进行了综述,为揭示抑郁症致病机制及其新药研发提供了理论依据。
引用
收藏
页码:180 / 185
页数:6
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