白介素10与动脉粥样硬化的研究现状

被引：10

作者：

王龙飞

谈敏

机构：

[1] 安徽医科大学附属省立医院干部病房

来源：

国外医学(老年医学分册) | 2008年 / 03期

关键词：

白介素10; 动脉粥样硬化; 基因多态性; 斑块稳定性;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

100201 [内科学];

摘要：

炎症在血管壁粥样硬化损害形成过程中起主要作用。脂质代谢、血管内皮损伤和炎症之间密切关联,动脉粥样硬化斑块的发生、发展与系统炎症密切相关,这些发现使抗炎细胞因子白介素10倍受关注。白介素10通过抑制多种促炎细胞因子的产生、下调细胞黏附分子的表达和抑制免疫反应等从从发挥抗动脉硬化作用。近几年,白介素10在抗动脉粥样硬化方面有新发现,在稳定性斑块与不稳定性斑块疾病血浆白介素10水平的临床研究结果不确定。因此,本文就白介素10在斑块内表达,抗动脉粥样硬化机制,白介素10基因多态性与动脉粥样硬化的关系以及白介素10血浆水平对动脉粥样斑块稳定性估计作一综述。

引用

页码：128 / 131

页数：4

共 5 条

[1]

Interleukin-10 expression is positively correlated with oxidized LDL deposition and inversely with T-lymphocyte infiltration in atherosclerotic intimas of human coronary arteries [J].

Sumiyoshi, S ;

Nakashima, Y ;

Chen, YX ;

Itabe, H ;

Sueishi, K .

PATHOLOGY RESEARCH AND PRACTICE, 2006, 202 (03) :141-150

[2]

Interleukin-18: Interleukin-10 ratio and in-hospital adverse events in patients with acute coronary syndrome [J].

Chalikias, GK ;

Tziakas, DN ;

Kaski, JC ;

Hatzinikolaou, EI ;

Stakos, DA ;

Tentes, IK ;

Kortsaris, A ;

Hatseras, DI .

ATHEROSCLEROSIS, 2005, 182 (01) :135-143

[3]

Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation [J].

van Haelst, PL ;

Tervaert, JWC ;

Bijzet, J ;

Baljé-Volkers, C ;

May, JF ;

Langeveld, B ;

Gans, ROB .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 138 (02) :364-368

[4]

C-reactive protein-induced production of interleukin-18 in human endothelial cells: a mechanism of orchestrating cytokine cascade in acute coronary syndrome [J].

Yamaoka-Tojo, M ;

Tojo, T ;

Masuda, T ;

Machida, Y ;

Kitano, Y ;

Kurosawa, T ;

Izumi, T .

HEART AND VESSELS, 2003, 18 (04) :183-187

[5]

Overexpression of Interleukin-10 by Activated T Lymphocytes Inhibits Atherosclerosis in LDL Receptor–Deficient Mice by Altering Lymphocyte and Macrophage Phenotypes.[J].Laura J. Pinderski;Michael P. Fischbein;Ganesamoorthy Subbanagounder;Michael C. Fishbein;Nobuhiko Kubo;Hilde Cheroutre;Linda K. Curtiss;Judith A. Berliner;William A. Boisvert.Circulation Research: Journal of the American Heart Association.2002, 10

← 1 →