COPD患者糖皮质激素不敏感的发生机制和应对策略研究进展

被引：13

作者：

张雪

费霞

张旻

机构：

[1] 上海交通大学附属第一人民医院呼吸科

来源：

国际呼吸杂志 | 2016年 / 36卷 / 21期

关键词：

慢性阻塞性肺疾病; 糖皮质激素; 糖皮质激素不敏感; 糖皮质激素抵抗;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

COPD是常见的慢性气道炎症性疾病,持续气道炎症导致不完全可逆的气流受限和肺结构破坏,引起肺功能进行性下降。尽管目前COPD的诊断和治疗已有很大的进步,但由于大气污染加重、烟雾和臭氧暴露增加,COPD的发病率和病死率在全球仍居高不下。糖皮质激素(glucocorticoid,GC)在哮喘等常见慢性炎症疾病和自身免疫性疾病中的治疗有效性已被临床实践证实,但大量实验研究表明,GC在COPD治疗中疗效欠佳,出现GC不敏感现象,因此关于COPD患者GC不敏感的机制和对策研究意义重大。本文就COPD患者气道炎症特征、GC不敏感发生机制、改善GC不敏感的应对策略进行综述。

引用

共 12 条

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