基质金属蛋白酶与脑缺血研究进展

[1] Multiple roles for MMPsand TIMPSs in cerebral ischemia. Cunningham LA,Wetzel M,Rosenberg GA. Glia . 2005

[2] Increase in plasma matrix metallopro-teinase-9 in acute stroke patients with thrombolysis failure. Heo JH,Kim SH,Lee KY,et al. Stroke . 2003

[3] Abnormal expression of matrixmetalloproteinases and tissue inhibitors of metalloproteinases in brainarteriovenous malformations. Hashimoto T,Wen G,Lawton MT,et al. Stroke . 2003

[4] Dual Role of Matrix Metalloproteinases(Matrixins)in Inti-mal Thickening and Atherosclerotic Plaque Rupture. Newby AC. Physiological Reviews . 2005

[5] Prospective,randomized,double-blindtrial investigating the effect of Doxycycline on matrix metalloproteinaseexpression within atherosclerotic carotid plaques. Axisa B,Loftus I,Ross Naylor A. Stroke . 2002

[6] Matrix metalloproteinase-9pretreatment level predicts intracranial hemorrhagic complications afterthrombolysis in human stroke. Montaner J,Molina CA,Monasterio J,et al. Circulation . 2003

[7] Matrix metalloproteinase ex-pression increases after cerebral focal ischemia in rats:inhibition of ma-trix metalloproteinase-9 reduces infarct size. Romanic AM,White RF,Arleth AJ,et al. Stroke . 1998

[8] Closure of the blood-brain barrier by ma-trix metalloproteinase inhibition reduces rtPA-mediated mortality in ce-rebral ischemia with delayed reperfusion. Pfefferkorn T,Rosenberg GA. Stroke . 2003

[9] Early appearance ofactivated matrix metalloproteinase-9 after focal cerebral ischemia inmice:a possible role in blood-brain barrier dysfunction. Gasche Y,Fujimura M,Morita-Fujimura Y,et al. Journal of Cerebral Blood Flow and Metabolism . 1999

[10] Doxycycline suppresses cerebral ma-trix metalloproteinase-9 and angiogenesis induced by focal hyperstimu-lation of vascular endothelial growth factor in a mouse model. Lee CZ,Xu B,Hashimoto T,et al. Stroke . 2004

[1] Multiple roles for MMPsand TIMPSs in cerebral ischemia. Cunningham LA,Wetzel M,Rosenberg GA. Glia . 2005

[2] Increase in plasma matrix metallopro-teinase-9 in acute stroke patients with thrombolysis failure. Heo JH,Kim SH,Lee KY,et al. Stroke . 2003

[3] Abnormal expression of matrixmetalloproteinases and tissue inhibitors of metalloproteinases in brainarteriovenous malformations. Hashimoto T,Wen G,Lawton MT,et al. Stroke . 2003

[4] Dual Role of Matrix Metalloproteinases(Matrixins)in Inti-mal Thickening and Atherosclerotic Plaque Rupture. Newby AC. Physiological Reviews . 2005

[5] Prospective,randomized,double-blindtrial investigating the effect of Doxycycline on matrix metalloproteinaseexpression within atherosclerotic carotid plaques. Axisa B,Loftus I,Ross Naylor A. Stroke . 2002

[6] Matrix metalloproteinase-9pretreatment level predicts intracranial hemorrhagic complications afterthrombolysis in human stroke. Montaner J,Molina CA,Monasterio J,et al. Circulation . 2003

[7] Matrix metalloproteinase ex-pression increases after cerebral focal ischemia in rats:inhibition of ma-trix metalloproteinase-9 reduces infarct size. Romanic AM,White RF,Arleth AJ,et al. Stroke . 1998

[8] Closure of the blood-brain barrier by ma-trix metalloproteinase inhibition reduces rtPA-mediated mortality in ce-rebral ischemia with delayed reperfusion. Pfefferkorn T,Rosenberg GA. Stroke . 2003

[9] Early appearance ofactivated matrix metalloproteinase-9 after focal cerebral ischemia inmice:a possible role in blood-brain barrier dysfunction. Gasche Y,Fujimura M,Morita-Fujimura Y,et al. Journal of Cerebral Blood Flow and Metabolism . 1999

[10] Doxycycline suppresses cerebral ma-trix metalloproteinase-9 and angiogenesis induced by focal hyperstimu-lation of vascular endothelial growth factor in a mouse model. Lee CZ,Xu B,Hashimoto T,et al. Stroke . 2004