尼莫通和川芎嗪对脑缺血-再灌注时c-fos和bcl-2蛋白表达的影响

被引：32

作者：

王春霞

包仕尧

刘春风

张志琳

机构：

[1] 苏州医学院附属第二医院神经科!江苏苏州

来源：

中国危重病急救医学 | 1999年 / 10期

关键词：

缺血再灌注,脑; c-fos; bcl-2; 尼莫通; 川芎嗪;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

目的：为临床应用尼莫通和川芎嗪治疗缺血性脑血管病提供充分的理论依据。方法：对实验大鼠于脑缺血前应用尼莫通和川芎嗪进行药物干预，然后采用免疫组化法检测脑缺血再灌注不同时间内ｃｆｏｓ及ｂｃｌ２蛋白表达的变化。结果：①与未用药组相比，尼莫通组和川芎嗪组大鼠脑缺血后的梗死体积显著减小，但两用药组之间相比无显著性差异；②尼莫通组和川芎嗪组脑缺血再灌注时皮质和基底节区ｃｆｏｓ的表达明显下降；而ｂｃｌ２的表达明显增高。结论：尼莫通和川芎嗪具有神经保护作用

引用

页码：609 / 612

页数：4

共 9 条

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