姜黄素新型靶向制剂研究进展

被引：16

作者：

毕文杰

穆小静

祖丽皮艳·阿布力米特

李泉丹

机构：

[1] 重庆大学化学化工学院药学系

来源：

中国药学杂志 | 2015年 / 50卷 / 04期

关键词：

姜黄素; 靶向给药; 脂质体; 配体-受体; 磁性氧化铁;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

靶向给药系统将药物通过局部给药选择性地浓集定位于靶组织、靶器官、靶细胞或细胞内结构,避免药物对健康组织造成损伤。姜黄素具有多种药理学活性,但是由于稳定性、水溶性差,生物利用度低限制了它的临床应用。近年来文献报道了多种姜黄素靶向新剂型,克服了上述缺点。本文主要从脂质体,配体-受体,磁性氧化铁等靶向载药体系等方面,论述姜黄素靶向新剂型的设计思路及其药理学效果。并分析靶向新剂型的优缺点以及未来发展趋势。

引用

页码：323 / 329

页数：7

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