依达拉奉防治缺血性脑损伤研究的新进展

被引：5

作者：

魏国荣

徐天昊

彭瑞云

机构：

[1] 军事医学科学院放射与辐射医学研究所

来源：

军事医学科学院院刊 | 2007年 / 04期

关键词：

依达拉奉; 自由基清除剂; 缺血性脑卒中; 新生儿缺血缺氧性脑病; 联合治疗;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

近年来,依达拉奉脑保护作用的研究取得了很大进展,尤以对缺血性脑卒中和新生儿缺血缺氧性脑病的防治研究最为深入,而联合治疗策略也得到了广泛的重视。本文就近5年这些热点研究的新进展进行综述。

引用

页码：384 / 387

页数：4

共 14 条

[1] MCI-186 administered to the maternal circulation inhibits fetal brain injury resulting from total umbilical cord occlusion in the chronically instrumented fetal lamb [J].

Masaoka, Naoki ;

Nakajima, Yoshiyuki ;

Watanabe, Masao ;

Hayakawa, Yasuhito ;

Nagaishi, Masaji ;

Yamamoto, Tatsuo ;

Honma, Taku ;

Oinuma, Toshimichi ;

Nemoto, Norimichi .

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2006, 19 (10) :625-631

[2]

Short-Term Administration of a New Free Radical Scavenger, Edaravone, Is More Effective Than its Long-Term Administration for the Treatment of Neonatal Hypoxic–Ischemic Encephalopathy[J] . Jesmin I. Noor,Tomoaki Ikeda,Kenichi Mishima,Naoya Aoo,Sumie Ohta,Nobuaki Egashira,Katsunori Iwasaki,Michihiro Fujiwara,Tsuyomu Ikenoue.Stroke . 2005 (11)

[3] Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain [J].

Zhang, N ;

Komine-Kobayashi, M ;

Tanaka, R ;

Liu, MZ ;

Mizuno, Y ;

Urabe, T .

STROKE, 2005, 36 (10) :2220-2225

[4]

Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model[J] . Kano,Harada,Katayama.Neurological Research . 2005 (5)

[5]

Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy[J] . Kuniaki Ogasawara,Keiko Yamadate,Masakazu Kobayashi,Hidehiko Endo,Takeshi Fukuda,Kenji Yoshida,Kazunori Terasaki,Takashi Inoue,Akira Ogawa.Surgical Neurology . 2005 (4)

[6]

Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus[J] . Hiroshi Otani,Hiroko Togashi,Subrina Jesmin,Ichiro Sakuma,Taku Yamaguchi,Machiko Matsumoto,Hitoshi Kakehata,Mitsuhiro Yoshioka.European Journal of Pharmacology . 2005 (2)

[7]

A free radical scavenger, edaravone, inhibits lipid peroxidation and the production of nitric oxide in hypoxic-ischemic brain damage of neonatal rats[J] . Jesmin I. Noor,Tomoaki Ikeda,Yuto Ueda,Tsuyomu Ikenoue.American Journal of Obstetrics and Gynecology . 2005 (5)

[8]

Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction[J] . Masaaki Uno,Keiko T. Kitazato,Atsuhiko Suzue,Kazuhito Matsuzaki,Masahumi Harada,Hiroyuki Itabe,Shinji Nagahiro.Free Radical Biology and Medicine . 2005 (8)

[9]

Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion[J] . Kazunori Toyoda,Kenichiro Fujii,Masahiro Kamouchi,Hiroshi Nakane,Shoji Arihiro,Yasushi Okada,Setsuro Ibayashi,Mitsuo Iida.Journal of the Neurological Sciences . 2004 (1)

[10] Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia [J].

Shichinohe, H ;

Kuroda, S ;

Yasuda, H ;

Ishikawa, T ;

Iwai, M ;

Horiuchi, M ;

Iwasaki, Y .

BRAIN RESEARCH, 2004, 1029 (02) :200-206

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