内质网应激调控骨关节炎软骨细胞凋亡的机制

被引：13

作者：

刘发元 ^{[1
]}

党传鹏 ^{[2
]}

翁霞萍 ^{[3
]}

林平冬 ^{[3
]}

叶蕻芝 ^{[1
]}

李西海 ^{[1
]}

机构：

[1] 福建中医药大学中西医结合研究院

[2] 青州市立医院

[3] 福建中医药大学药学院

来源：

风湿病与关节炎 | 2014年 / 3卷 / 11期

关键词：

骨关节炎; 内质网应激; 软骨细胞; 凋亡;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

探讨内质网应激调控软骨细胞凋亡的机制,旨在为骨关节炎的防治提供可行性的研究导向。内质网是细胞内重要的细胞器,各种刺激因素易引起内质网应激,导致内质网相关性死亡。软骨细胞凋亡在骨关节炎软骨退变进程中发挥重要的调控作用,而处于特殊缺氧环境的软骨细胞对各种刺激因素敏感,微环境的改变使软骨细胞发生内质网应激,导致内质网相关性死亡。

引用

页码：55 / 58

页数：4

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