胶原酶诱导的鼠类退行性膝骨关节炎模型应用进展

被引：16

作者：

刘军 ^{[1
]}

潘建科 ^{[2
]}

黄永明 ^{[1
]}

杨伟毅 ^{[1
]}

李想 ^{[1
]}

曹学伟 ^{[1
]}

机构：

[1] 广东省中医院骨科

[2] 广州中医药大学第二临床医学院

来源：

实用医学杂志 | 2013年 / 29卷 / 23期

基金：

广东省科技计划;

关键词：

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>动物模型为骨关节炎的研究做出了巨大贡献。随着全球老龄化速度加快,退行性膝骨关节炎(knee osteoarthritis,KOA)的发病率越来越高,动物模型的构建是开展退行性KOA研究面临的首要问题。van der Kraan等[1]率先开展鼠类退行性KOA模型的研究,发现胶原酶可通过损伤含有Ⅰ型胶原的关节结构,例如肌腱、韧带和半月板等,从而导

引用

页码：3949 / 3950

页数：2

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