白血病细胞株红细胞生成素受体的表达及机能的研究

被引：3

作者：

樊华

杉田完尔

翟明

中泽真平

机构：

[1] 中国医科大学第一临床学院!辽宁

[2] 日本山梨医科大学

来源：

白血病 | 2000年 / 02期

关键词：

白血病; 细胞株; Epo; EpoR; 增殖;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

目的 :检测白血病细胞株 Epo R的表达和 Epo刺激的增殖反应。方法 :流式细胞仪检测白血病细胞株 Epo R的表达 ,3H - Td R掺入法检测 Epo刺激的增殖反应。结果 :除 T淋巴细胞系外 ,其余细胞株均为阳性 ,Epo R阳性率在 18%～ 99%间 ,均值 5 2 % ,三型间 Epo R阳性率的差异没有统计学意义 ;9株中 7株被刺激而显著增殖 ,P<0 .0 5 ,Epo R阳性率不与增殖反应相一致。结论 :白血病细胞株中可有 Epo R的表达 ;Epo可引起部分白血病细胞增殖 ;Epo R阳性率不与增殖反应相一致。

引用

页码：98 / 100

页数：3

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