白血病细胞株红细胞生成素受体的表达及机能的研究

被引:3
作者
樊华
杉田完尔
翟明
中泽真平
机构
[1] 中国医科大学第一临床学院!辽宁
[2] 日本山梨医科大学
关键词
白血病; 细胞株; Epo; EpoR; 增殖;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
目的 :检测白血病细胞株 Epo R的表达和 Epo刺激的增殖反应。方法 :流式细胞仪检测白血病细胞株 Epo R的表达 ,3H - Td R掺入法检测 Epo刺激的增殖反应。结果 :除 T淋巴细胞系外 ,其余细胞株均为阳性 ,Epo R阳性率在 18%~ 99%间 ,均值 5 2 % ,三型间 Epo R阳性率的差异没有统计学意义 ;9株中 7株被刺激而显著增殖 ,P<0 .0 5 ,Epo R阳性率不与增殖反应相一致。结论 :白血病细胞株中可有 Epo R的表达 ;Epo可引起部分白血病细胞增殖 ;Epo R阳性率不与增殖反应相一致。
引用
收藏
页码:98 / 100
页数:3
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