有氧运动抑制自发性高血压大鼠胸主动脉平滑肌K通道蛋白表达下调

被引：5

作者：

李圳程

鲁妮

石丽君

机构：

[1] 北京体育大学运动生理教研室

来源：

北京体育大学学报 | 2014年 / 37卷 / 06期

关键词：

有氧运动; 自发性高血压大鼠; 胸主动脉平滑肌; KV通道;

D O I：

暂无

中图分类号：

G804.2 [运动生理学];

学科分类号：

040211 [体育与运动心理学];

摘要：

目的:观察有氧运动对自发性高血压大鼠(SHR)离体胸主动脉反应性及电压门控钾通道(KV)蛋白表达的影响,探讨运动降低血压的血管平滑肌钾通道机制。方法:24只雄性SHR随机平均分为安静组(SHR-SED)和运动组(SHR-EX),另选用同龄雄性WKY大鼠作为正常血压对照组。SHR-EX组进行8周有氧运动,坡度0°,20 m/min,60 min/d,5 d/周。8周后,检验离体胸主动脉对去甲肾上腺素(NE)、4-氨基吡啶(4-AP)的反应性。另用免疫组化DAB法和Western blot法测定胸主动脉平滑肌KV1.2和KV1.5的表达情况。结果:1)SHR-EX组血压显著低于SHR-SED组1)SHR-EX组离体胸主动脉对NE的敏感性小于SHR-SED组。2)4-AP诱发的血管收缩反应在SHE-EX组中显著大于SHR-SED组。3)SHR-EX组KV1.2和KV1.5表达均显著高于SHE-SED组,有氧运动显著抑制KV1.2和KV1.5表达的下调。结论:长期规律的有氧运动训练可降低SHR的收缩压,减弱胸主动脉对缩血管物质的反应性,其重要机制之一为有氧运动显著抑制高血压诱导的平滑肌细胞KV通道蛋白表达下调。

引用

页码：49 / 53

页数：5

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