尼可地尔对PCI相关心肌损伤及再发心绞痛症状的影响

被引：17

作者：

杨树涵

王成

刘艳宾

韩明磊

机构：

[1] 河南省新乡市中心医院心内一科

来源：

天津医药 | 2014年 / 42卷 / 10期

关键词：

血管成形术,经腔,经皮冠状动脉; 心绞痛,不稳定型; 肌酸激酶,MB型; 肌钙蛋白I; 尼可地尔;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

摘要：

目的观察经皮冠脉介入治疗(PCI)术前应用尼可地尔对不稳定型心绞痛患者PCI相关心肌损伤及术后长期应用对心绞痛的影响。方法选择行PCI的不稳定型心绞痛患者91例,随机分为尼可地尔组和常规组,常规组患者行优化冠心病药物治疗,尼可地尔组在此基础上给予尼可地尔5 mg口服,每日3次,应用1周行PCI。术前,术后6、18、24 h检测血清肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白I(cTnI),术后6个月随访心绞痛缓解情况及主要心血管不良事件。结果最终有75例完成研究,尼可地尔组37例,常规组38例,2组患者在住院期间和术后随访时均未发生死亡、心肌梗死、脑卒中,术后尼可地尔组血清CK-MB和cTnI水平较常规组降低(P<0.05),尼可地尔组患者心绞痛症状缓解较常规组明显(P<0.05)。结论尼可地尔能减轻不稳定型心绞痛PCI相关心肌损伤,长期应用对心绞痛有良好的缓解作用。

引用

页码：1026 / 1028

页数：3

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