Runx2在骨形成中的作用及调控

被引：25

作者：

李娜

代晓霞

机构：

[1] 西安交通大学医学部公共卫生学院

来源：

国外医学(医学地理分册) | 2018年 / 39卷 / 04期

关键词：

Runx2; 成骨细胞; 软骨细胞; 表达调控;

D O I：

暂无

中图分类号：

R68 [骨科学（运动系疾病、矫形外科学）];

学科分类号：

100220 [骨科学];

摘要：

正常情况下,骨形成和骨吸收处于动态平衡。Runx2(runt-related transcription factor 2)是骨发育过程中重要的转录因子,对成骨细胞的分化、软骨细胞成熟、破骨细胞的分化及细胞外基质的分泌都有重要的调控作用。因此,研究Runx2基因的表达调控、传导通路十分必要,对治疗骨代谢疾病具有重要意义。本文将从Runx2的结构功能和表达调控对成骨细胞的影响进行阐述。

引用

页码：353 / 356

页数：4

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