脓毒症心肌抑制的诊治进展

被引：34

作者：

李真玉 ^{[1
]}

陈兵 ^{[1
]}

李广平 ^{[2
]}

机构：

[1] 天津医科大学第二医院急诊科

[2] 天津市心血管病离子与分子机能重点实验室心脏科

来源：

中国循环杂志 | 2015年 / 30卷 / 07期

关键词：

脓毒症; 心功能不全; 细胞凋亡; 细胞因子; 肌钙蛋白;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

脓毒症是感染引起的全身炎症反应综合征,进一步发展可致严重脓毒症、脓毒性休克,是重症监护病房的主要死因。脓毒症患者最终死于心血管功能衰竭,其中心肌抑制（SIMD）是主要原因。约50%的严重脓毒症患者会出现不同程度的心肌抑制,病死率高达70%90%。尽管对脓毒症的病理生理机制研究不断深入,新的治疗理念、治疗方法不断出现,但病死率仍居高不下。本文主要对目前脓毒症心肌抑制的发病机制、血流动力学变化、评估方法及治疗进展做一综述,以期对将来基础和临床研究有所帮助。

引用

收藏

页码：705 / 707

页数：3

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