抗高脂血症:新靶点与新药研发

被引：12

作者：

阮文臣 ^{[1
]}

张天宁 ^{[1
]}

李佳 ^{[2
]}

张陆勇 ^{[1
]}

庞涛 ^{[1
]}

机构：

[1] 中国药科大学江苏省新药筛选重点实验室天然药物活性组分与药效国家重点实验室

[2] 中国科学院上海药物研究所国家新药筛选中心

来源：

药学进展 | 2017年 / 41卷 / 01期

关键词：

高脂血症; 胆固醇; 三酰甘油; 脂质代谢; 药物靶点; 新药研发;

D O I：

暂无

中图分类号：

R972 [心血管系统药物];

学科分类号：

100117 [系统生物医学];

摘要：

高脂血症是引发各种心脑血管疾病最主要的因素之一,通过调节血脂来降低心脑血管疾病的发生率,具有重大意义。从调控内源性脂质合成、外源性脂质吸收与胆汁酸重吸收、血浆脂蛋白代谢以及脂质代谢等4个方面出发,系统概述抗高脂血症的新靶点与新药研究进展,旨在为高脂血症的治疗药物开发提供参考。

引用

页码：56 / 64

页数：9

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