重性抑郁症首发未用药患者的枕叶GABA波谱研究

被引：7

作者：

宋哲 ^{[1
,2
]}

黄沛钰 ^{[1
,2
]}

邱丽华 ^{[3
]}

吴杞柱 ^{[3
]}

龚启勇 ^{[3
]}

张必达 ^{[4
]}

Heberlein Keith ^{[4
]}

谢鹏 ^{[1
,2
]}

机构：

[1] 重庆医科大学神经科学研究中心

[2] 重庆市神经生物学重点实验室

[3] 四川大学华西医院放射科华西磁共振研究中心

[4] 西门子中国有限公司医疗系统集团

来源：

生物医学工程学杂志 | 2012年 / 02期

关键词：

抑郁症; 枕叶; γ-氨基丁酸; 磁共振波谱;

D O I：

暂无

中图分类号：

R749.41 [];

学科分类号：

100205 ;

摘要：

在中枢神经系统中,γ-氨基丁酸(GABA)是主要的抑制性神经递质。由于GABA在普通磁共振波谱(MRS)上为低谱峰信号,且与其他物质的波峰重叠,因此难以准确得出其在脑内感兴趣区的含量。为观察抑制性神经递质GABA在首发未用药重性抑郁症(MDD)患者枕叶的含量改变,本研究采用了J-耦合编辑点分辨波谱(MEGA-PRESS)技术检测18例首发未用药重性MDD(17项HAMD评分>18分)患者和23名健康对照被试枕叶皮层的GABA含量。采用双样本t检验及相关分析进行统计学处理。结果表明,病例组枕叶GABA含量(11.35±3.26)显著低于对照组(27.30±8.87),P<0.001。病例组枕叶GABA含量与汉密尔顿抑郁量表及贝克抑郁自评量表相关性均不显著。首发未用药重性MDD患者的枕叶GABA含量降低,可能导致其视觉功能下降。

引用

页码：233 / 236

页数：4

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