充血性心力衰竭患儿心肌β肾上腺素能受体系统在心室重塑中作用的研究

被引:6
作者
易岂建
钱永如
李仕章
刘晓燕
机构
[1] 重庆医科大学儿童医院
关键词
心力衰竭.充血性;心室重塑;β受体.肾上腺素能;
D O I
暂无
中图分类号
R541.61 [];
学科分类号
摘要
目的:研究充血性心力衰竭(CHF)患儿心肌β肾上腺素能受体系统在左室重塑中的作用。方法:采用高效液相色谱电化学法对18例CHF患儿测定血浆去甲肾上腺素(NE)、肾上腺素(E)浓度,用3Hdihydroalpneolol(3HDHA)放射配基结合分析法测定外周血淋巴细胞β受体密度最大值(Bmax),并以心脏超声仪测定和计算左心室心肌重量指数(LVMI)。结果:CHF患儿LVMI正常组血浆NE、E分别为(520.1±187.3)μg/L和(294.1±178.4)μg/L,显著高于正常对照组〔(189.3±92.4)μg/L和(94.5±45.1)μg/L;t=6.538和t=10.27,P均<0.001〕;Bmax〔(378.7±97.2)fmol/106〕低于正常对照组〔(568.2±101.8)fmol/106,t=4.876,P<0.001〕,LVMI增高组Bmax〔(268.5±85.6)fmol/106〕显著低于LVMI正常组〔(378.7±97.2)fmol/106〕;Bmax与LVMI显著负相关(r=-0.69,P<0.01)。结论:血浆NE、E浓度和外周血淋巴细胞Bmax可作为判断心功能受损程
引用
收藏
页码:38 / 40
页数:3
相关论文
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