肿瘤干细胞与胃癌

被引：15

作者：

张朝军 ^{[1
]}

李晨蔚 ^{[2
]}

杨桦 ^{[1
]}

何凤田 ^{[3
]}

机构：

[1] 第三军医大学新桥医院普外科

[2] Department of Surgery,University of Michigan Medical Center, East Medical Center Drive

[3] 第三军医大学生物化学与分子生物学教研室

来源：

中国生物化学与分子生物学报 | 2009年 / 25卷 / 10期

关键词：

胃癌细胞; 肿瘤干细胞; 肿瘤治疗;

D O I：

10.13865/j.cnki.cjbmb.2009.10.015

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

最近的一项研究报导,采用流式细胞仪分选技术从人胃癌细胞株中分离出CD44+胃癌干细胞.20～30×103个CD44+细胞入NOD/SCID鼠腹部皮下和胃浆膜下能形成胃癌移植瘤,100×103个CD44-的细胞入NOD/SCID鼠体内不形成肿瘤.采用无血清、无粘附间质的干细胞体外培养方法,发现CD44+的细胞能形成肿瘤微球体,具有自我更新能力,而CD44-的细胞则不形成球形克隆.上述的实验结果说明,在人胃癌细胞株中存在胃癌肿瘤干细胞.据此可以相信,胃癌干细胞是胃癌细胞中具有自我更新及分化潜能的一小群细胞,不能被目前的化疗、放疗等抗癌治疗措施所杀灭,是胃癌术后复发、肿瘤进展扩散转移的根源.胃癌干细胞可能来源于骨髓干细胞.随着对胃癌肿瘤干细胞生物学研究的深入,必将为胃癌的临床诊断和治疗提供新的策略.

引用

收藏

页码：889 / 895

页数：7

相关论文

共 11 条

[1]

Bone marrow-derived cells and epithelial tumours: more than just an inflammatory relationship [J].

Alison, Malcolm R. ;

Lim, Susan ;

Houghton, Jean-Marie .

CURRENT OPINION IN ONCOLOGY, 2009, 21 (01) :77-82

[2]

Cancer stem cells and survival pathways [J].

Hambardzumyan, Dolores ;

Becher, Oren J. ;

Holland, Eric C. .

CELL CYCLE, 2008, 7 (10) :1371-1378

[3]

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer [J].

Hermann, Patrick C. ;

Huber, Stephan L. ;

Herrler, Tanja ;

Aicher, Alexandra ;

Ellwart, Joachim W. ;

Guba, Markus ;

Bruns, Christiane J. ;

Heeschen, Christopher .

CELL STEM CELL, 2007, 1 (03) :313-323

[4]

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity [J].

Clement, Virginie ;

Sanchez, Pilar ;

de Tribolet, Nicolas ;

Radovanovic, Ivan ;

Altaba, Ariel Ruiz I. .

CURRENT BIOLOGY, 2007, 17 (02) :165-172

[5]

Epithelial stem cells: Turning over new leaves [J].

Blanpain, Cedric ;

Horsley, Valerie ;

Fuchs, Elaine .

CELL, 2007, 128 (03) :445-458

[6]

Prospective identification of a multilineage progenitor in murine stomach epithelium [J].

Qiao, Xiaotan T. ;

Ziel, Joshua W. ;

Mckimpson, Wendy ;

Madison, Blair B. ;

Todisco, Andrea ;

Merchant, Juanita L. ;

Samuelson, Linda C. ;

Gumucio, Deborah L. .

GASTROENTEROLOGY, 2007, 133 (06) :1989-1998

[7]

Selective Targeting of Cancer Stem Cells.[J].Hasan Korkaya;Max S. Wicha.BioDrugs.2007, 5

[8]

Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer [J].

Katoh, Masaru .

CANCER BIOLOGY & THERAPY, 2007, 6 (06) :832-839

[9]

Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer [J].

Fukaya, Masahide ;

Isohata, Noriyuki ;

Ohta, Hiroyuki ;

Aoyagi, Kazuhiko ;

Ochiya, Takahiro ;

Saeki, Norihisa ;

Yanagihara, Kazuyoshi ;

Nakanishi, Yukihiro ;

Taniguchi, Hirokazu ;

Sakamoto, Hiromi ;

Shimoda, Tadakazu ;

Nimura, Yuji ;

Yoshida, Teruhiko ;

Sasaki, Hiroki .

GASTROENTEROLOGY, 2006, 131 (01) :14-29

[10]

Hedgehog signaling pathway and gastric cancer [J].

Katoh, Y ;

Katoh, M .

CANCER BIOLOGY & THERAPY, 2005, 4 (10) :1050-1054