Calnexin/Calreticulin循环与糖蛋白内质网相关性降解

被引:5
作者
林胜利
李载权
唐朝枢
机构
[1] 北京大学医学部基础医学院生物化学与分子生物学系
[2] 北京大学医学部基础医学院生理学与病理生理学系 北京市
[3] 北京市
关键词
Calnexin/Calreticulin循环; 糖蛋白折叠; 糖蛋白内质网相关性降解;
D O I
暂无
中图分类号
R341 [];
学科分类号
1001 ;
摘要
Calnexin/Calreticulin循环与糖蛋白内质网相关性降解 (GERAD)是真核细胞内负责糖蛋白折叠质量的重要监控机制 ,监督糖蛋白在内质网中空间构象的正确折叠 ,促进未完全折叠糖蛋白再折叠 ,错误折叠糖蛋白经GERAD途径被降解。内质网应激引起内质网功能障碍时 ,Calnexin/Calreticulin循环和 (或 )GERAD发生异常 ,错误折叠的糖蛋白在内质网堆积导致细胞功能障碍和某些疾病的发生。错误折叠糖蛋白从Calnexin/Calreticulin循环释放到GERAD一系列途径的分子机理现已逐渐明了 ,了解糖蛋白Calnexin/Calreticulin循环与内质网相关性降解过程对进一步设计针对病毒性肝炎、帕金森病等疾病的治疗方案有重要的指导意义。
引用
收藏
页码:298 / 301
页数:4
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