高血压肾损害相关上皮-间充质转化机制研究进展

被引：15

作者：

方媛 ^{[1
]}

丁康 ^{[1
]}

方祝元 ^{[2
]}

机构：

[1] 南京中医药大学第三附属医院急诊科

[2] 南京中医药大学附属医院

来源：

中华高血压杂志 | 2018年 / 26卷 / 04期

关键词：

D O I：

10.16439/j.cnki.1673-7245.2018.04.005

中图分类号：

R544.1 [高血压]; R692 [肾疾病];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

<正>高血压可引起心、脑、肾、眼、血管等诸多靶器官的并发症。在我国老年患者中,高血压肾损害甚至已取代肾小球疾病成为导致终末期肾病（end stage renal disease,ESRD）的第二位病因[1]。高血压肾损害机制尚不完全明朗,目前认为高血压患者体内肾素血管紧张素醛固酮系统(renin angiotensin aldosterone sys-

引用

页码：312 / 316

页数：5

共 7 条

[1]

Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells.[J]..Acta Pharmacologica Sinica.2006, 08

[2]

Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System [J].

Zhou, Lili ;

Mo, Hongyan ;

Miao, Jinhua ;

Zhou, Dong ;

Tan, Roderick J. ;

Hou, Fan Fan ;

Liu, Youhua .

AMERICAN JOURNAL OF PATHOLOGY, 2015, 185 (12) :3211-3223

[3]

The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling.[J].Maricica Pacurari;Ramzi Kafoury;Paul B. Tchounwou;Kenneth Ndebele;Jean-Marc Cavaillon.International Journal of Inflammation.2014,

[4]

Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy [J].

Loeffler, Ivonne ;

Liebisch, Marita ;

Wolf, Gunter .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2012, 303 (05) :F733-F745

[5]

Diabetes and hypertension have become leading causes of CKD in Chinese elderly patients: a comparison between 1990–1991 and 2009–2010 [J].

Yali Cao ;

Wenge Li ;

Guannan Yang ;

Yutian Liu ;

Xin Li .

International Urology and Nephrology, 2012, 44 :1269-1276

[6]

Cooperation; amplification; and feed-back in epithelial–mesenchymal transition.[J].Antonio García de Herreros;Josep Baulida.BBA - Reviews on Cancer.2012, 2

[7]

医学细胞生物学.[M].陈誉华; 主编.人民卫生出版社.2008,

← 1 →