低密度脂蛋白受体相关蛋白与动脉粥样硬化的关系

被引：33

作者：

李颖莉

机构：

[1] 天津市胸科医院心内科天津市心血管病研究所天津

来源：

中国分子心脏病学杂志 | 2003年 / 03期

关键词：

低密度脂蛋白受体相关蛋白; 动脉粥样硬化;

D O I：

10.16563/j.cnki.1671-6272.2003.03.010

中图分类号：

R543 [血管疾病];

学科分类号：

100201 [内科学];

摘要：

低密度脂蛋白受体相关蛋白(low density lipoprotein receptor-related protein,LRP)是近年来发现的一种细胞表面蛋白,属于一种内吞性受体,系低密度脂蛋白受体(low density lipoprotein receptor,LDLR)基因家族中的一员。由于其能够与多种结构及功能各异的配体相互作用,不仅可以对血脂的动态平衡及纤溶功能的稳定进行调节,而且能参与多种生长因子、细胞激酶生物学效应的发挥。近来有研究表明LRP与动脉粥样硬化发生发展的多个环节密切相关并将其视为动脉粥样硬化性疾病又一新的危险因子。因而对其理化特性及生物学功能进行深入研究具有重要的理论及实际意义。

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