PI3K/Akt信号通路调节心脏功能的研究进展

被引：33

作者：

杨立霞 ^{[1
]}

王楠 ^{[2
]}

刘洋 ^{[1
]}

机构：

[1] 甘肃中医药大学临床医学院心血管内科

[2] 甘肃省人民医院干三心内科

来源：

心脏杂志 | 2018年 / 30卷 / 03期

关键词：

磷脂酰肌醇-3激酶; 丝(苏)氨酸激酶; 心脏功能; 凋亡;

D O I：

10.13191/j.chj.2018.0083

中图分类号：

R541 [心脏疾病];

学科分类号：

100201 [内科学];

摘要：

PI3K/Akt是调节心脏功能的一条重要的信号转导通路,主要通过血管内皮生长因子介导血管生成、抑制心肌细胞凋亡、重构心室、促进细胞能量代谢等方面调节心脏功能。研究发现PI3K/Akt信号通路在内分泌疾病、肾病、肝纤维化、肿瘤及心血管疾病的发生、发展中起着重要作用。本文就PI3K/Akt信号通路调节心脏功能的分子机制作一阐述。

引用

页码：344 / 347

页数：4

共 14 条

[1]

Diagnostic and prognostic value of circulating microRNAs in heart failure with preserved and reduced ejection fraction [J].

Schulte, Christian ;

Westermann, Dirk ;

Blankenberg, Stefan ;

Zeller, Tanja .

WORLD JOURNAL OF CARDIOLOGY, 2015, 7 (12) :843-860

[2]

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? [J].

Singh, Shikha Satendra ;

Yap, Wei Ney ;

Arfuso, Frank ;

Kar, Shreya ;

Wang, Chao ;

Cai, Wanpei ;

Dharmarajan, Arunasalam M. ;

Sethi, Gautam ;

Kumar, Alan Prem .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (43) :12261-12273

[3]

Targeting the PI3K-AKT-mTOR signaling network in cancer.[J].Khurum H. Khan;Timothy A. Yap;Li Yan;David Cunningham;.Chinese Journal of Cancer.2013, 05

[4]

先天性心脏病胎儿心脏及胎盘组织中MAPK及Akt信号通路分子的变化.[J].徐洁;杨中州;张姝;吴少亘;胡娅莉;.中国当代儿科杂志.2010, 05

[5]

Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2-and PI3K/AKT-associated pathways [J].

Wei, Can ;

Li, Hong-Zhu ;

Wang, Yue-Hong ;

Peng, Xue ;

Shao, Hong-Jiang ;

Li, Hong-Xia ;

Bai, Shu-Zhi ;

Lu, Xiao-Xia ;

Wu, Ling-Yun ;

Wang, Rui ;

Xu, Chang-Qing .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 37 (01) :39-46

[6]

Flavonoids Extraction from Propolis Attenuates Pathological Cardiac Hypertrophy through PI3K/AKT Signaling Pathway.[J].Guang-wei Sun;Zhi-dong Qiu;Wei-nan Wang;Xin Sui;Dian-jun Sui;Yoshiji Ohta.Evidence-Based Complementary and Alternative Medi.2016,

[7]

Targeting N-cadherin Increases Vascular Permeability and Differentially Activates AKT in Melanoma [J].

Turley, Ryan S. ;

Tokuhisa, Yoshihiro ;

Toshimitsu, Hiroaki ;

Lidsky, Michael E. ;

Padussis, James C. ;

Fontanella, Andrew ;

Deng, Wanleng ;

Augustine, Christina K. ;

Beasley, Georgia M. ;

Davies, Michael A. ;

Dewhirst, Mark W. ;

Tyler, Douglas S. .

ANNALS OF SURGERY, 2015, 261 (02) :368-377

[8]

Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival [J].

Lin, Zhiqiang ;

Zhou, Pingzhu ;

von Gise, Alexander ;

Gu, Fei ;

Ma, Qing ;

Chen, Jinghai ;

Guo, Haidong ;

van Gorp, Pim R. R. ;

Wang, Da-Zhi ;

Pu, William T. .

CIRCULATION RESEARCH, 2015, 116 (01) :35-U98

[9]

Astragalus Polysaccharide Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the PI3k/Akt and p38MAPK Pathways.[J].Yuan Cao;Yang Ruan;Tao Shen;Xiuqing Huang;Meng Li;Weiwei Yu;Yuping Zhu;Yong Man;Shu Wang;Jian Li;Qingping Feng.Oxidative Medicine and Cellular Longevity.2014,

[10]

Inhibition of Phosphatidylinositol 3-kinase/Akt Signaling Attenuates Hypoxia-induced Pulmonary Artery Remodeling and Suppresses CREB Depletion in Arterial Smooth Muscle Cells [J].

Garat, Chrystelle V. ;

Crossno, Joseph T., Jr. ;

Sullivan, Timothy M. ;

Reusch, Jane E. B. ;

Klemm, Dwight J. .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2013, 62 (06) :539-548

← 1 2 →