促性腺激素释放激素类似物简易激发试验对性早熟诊断的评价

被引：20

作者：

马华梅

杜敏联

陈红珊

李燕虹

苏喆

机构：

[1] 中山大学附属第一医院儿科

[2] 中山大学附属第一医院儿科广州

[3] 广州

来源：

中华内分泌代谢杂志 | 2002年 / 04期

关键词：

促性腺激素释放激素; 青春期,早熟;

D O I：

暂无

中图分类号：

R585 [松果体疾病、早发青春期症（性早熟）];

学科分类号：

1002 ; 100201 ;

摘要：

目的　评价促性腺激素释放激素类似物 (GnRHa)简易激发试验对性早熟的诊断价值。方法　乳房发育提前的 74例女孩 (就诊时行 0、30和 6 0min简易GnRHa激发试验 )被分为 4组 :真性性早熟 (CPP)B2 组 19例 ;CPPB3 组 2 3例 ;单纯性乳房早发育 (PT)组 2 2例 ;外周性性早熟 (PPP)组 10例。对各组激发试验进行比较和分析。结果　PPP组 3个时相血清FSH及LH浓度差异无显著性。PT、CPPB2 和CPPB3 组 3个时相的血清FSH及LH浓度差异均有显著性 (P <0 .0 1)。PT组ΔFSH(8.0± 3.2 )IU/L显著高于ΔLH〔(1.9± 1.4 )IU/L ,P <0 .0 1〕。CPPB2 组ΔFSH(7.0± 2 .9)IU/L与ΔLH(8.2± 6 .7)IU/L差异无显著性。CPPB3 组ΔLH(2 3.0± 2 2 .0 )IU/L显著高于ΔFSH〔(9.0± 4 .3)IU/L ,P <0 .0 5〕。PT、CPPB2 和CPPB3 组的ΔLH及峰LH/FSH〔(0 .4± 0 .2 )、 (1.1± 0 .8)和 (1.9± 1.7)〕差异有显著性 (P <0 .0 1)。以LH峰值≥ 4 .4IU/L和峰LH/FSH≥ 0 .4 6为前提 ,诊断CPP的灵敏度和特异度分别为 90 .5 %和 90 .9%。结论　PPP组垂体对GnRHa无应答。PT组反应以FSH升高为主 ,CPPB2 和CPPB3 组以LH升高为主。此激发试验对性早熟性质具早期鉴别诊断价值

引用

页码：50 / 54

页数：5

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