基于中医药特点的中药体内外药效物质组生物/化学集成表征新方法

被引：30

作者：

齐炼文 ^{[1
]}

周建良 ^{[1
]}

郝海平 ^{[2
]}

李会军 ^{[1
]}

闻晓东 ^{[1
]}

陈君 ^{[1
]}

杨中林 ^{[1
]}

李萍 ^{[1
]}

王广基 ^{[2
]}

机构：

[1] 中国药科大学现代中药教育部重点实验室

[2] 中国药科大学药物代谢动力学重点实验室

来源：

中国药科大学学报 | 2010年 / 41卷 / 03期

基金：

国家自然科学基金重大研究计划; 国家杰出青年科学基金;

关键词：

中药药效物质; 生物捕集-化学集成表征; 多组分表征; 质量控制; 整合作用; 体内动态药效物质;

D O I：

暂无

中图分类号：

R284.1 [化学分析与鉴定];

学科分类号：

1008 ;

摘要：

中药药效物质基础研究一直是中医药现代化的关键问题之一。近几十年来,中药药效物质研究虽已取得了长足的进步,但还存在明显不足,符合中药特点的药效物质研究关键技术体系尚不完善。作者及其研究团队针对中药药效物质基础的国内外研究现状,集成多学科的理论和技术,在学术思想、研究思路和研究方法等方面进行了探索,通过近十年的系统研究,建立了基于整体观、符合中医药特点和具有普适性的中药复杂药效物质研究关键技术与方法学体系,包括中药多组分表征技术、中药生物体内动态药效物质研究技术、生物捕集-化学集成表征新技术、中药多成分整合作用研究技术、适宜于中药特点的多指标质量控制技术。研究成果为中药药效物质基础及作用机制研究提供了技术支撑。

引用

页码：195 / 202

页数：8

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