金天格胶囊对骨质疏松性骨折大鼠血清IL-2、IL-4和TNF-α表达的影响

被引：24

作者：

赵玉玺 ^{[1
]}

张彬 ^{[1
]}

湛梅圣 ^{[1
]}

王万垠 ^{[1
]}

杨建强 ^{[1
]}

胡耀芬 ^{[1
]}

孙海萍 ^{[1
]}

吴璇 ^{[2
]}

机构：

[1] 湖北省枣阳市第一人民医院骨科

[2] 湖北省枣阳市第一人民医院五官科

来源：

中国骨质疏松杂志 | 2015年 / 21卷 / 07期

关键词：

骨质疏松性骨折; 金天格胶囊; IL-2; IL-4; TNF-α;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的研究一种新的国家一类中药金天格胶囊对骨质疏松性骨折大鼠骨折愈合过程中细胞因子的影响。方法建立绝经后骨质疏松性骨折大鼠模型,给予雌激素及不同浓度的金天格胶囊灌胃,并于灌胃治疗5周后,采用酶联免疫吸附法(ELISA)测定白细胞介素-2(IL-2)、白细胞介素-4(IL-4)及肿瘤坏死因子-α(TNF-α)的表达。结果模型组大鼠的IL-2、IL-4的阳性表达明显降低、TNF-α的阳性表达明显升高(P<0.05);中、低剂量的金天格胶囊可使大鼠的IL-2、IL-4的阳性表达明显升高、TNF-α的阳性表达明显降低(P<0.05),而高剂量金天格胶囊的干预效果不显著(P>0.05)。结论 1IL-2、IL-4是促进骨质疏松性骨折愈合的细胞因子,与TNF-α的作用相反2金天格胶囊对骨质疏松性骨折大鼠的愈合具有促进作用。

引用

页码：796 / 800

页数：5

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