亚精胺对鼠免疫器官指数及炎症因子表达的影响

被引：11

作者：

徐麒麟

康波

姜冬梅

魏春叶

贾医林

易治鑫

陈咨余

机构：

[1] 四川农业大学动物科技学院/畜禽遗传资源发掘与创新利用四川省重点实验室

来源：

浙江农业学报 | 2017年 / 29卷 / 02期

关键词：

亚精胺; 胸腺指数; 脾脏指数; 炎症因子;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

为阐明亚精胺对鼠免疫器官指数、胸腺和脾脏组织炎症因子表达的影响,采用0、0.05、0.10和0.15mg·g-1(体质量)亚精胺腹腔注射6周龄昆明小白鼠,测定鼠胸腺和脾脏指数,并定量检测胸腺和脾脏组织TNF-α、IL-1β、IL-6和IFN-γ表达量。结果表明:注射0.15 mg·g-1亚精胺组鼠胸腺指数和脾脏指数显著(P<0.05)低于对照组;0.10 mg·g-1亚精胺组胸腺组织IFN-γ表达量显著(P<0.05)高于对照组;0.05 mg·g-1亚精胺组鼠脾脏组织TNF-α和IL-1β表达量显著(P<0.05)低于对照组,0.10 mg·g-1亚精胺组脾脏组织IL-6和IFN-γ表达量均显著(P<0.05)高于对照组,0.15 mg·g-1组脾脏组织TNF-α表达量显著(P<0.05)低于对照组。由此可见,亚精胺对炎症因子表达具有组织特异性和剂量依赖性。低浓度亚精胺能抑制炎症因子表达发挥抗炎作用,随着亚精胺浓度增加则表现为诱导炎症。

引用

页码：200 / 205

页数：6

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