肝纤维化病程中Kupffer细胞与HSC的相互关系(综述)

被引：7

作者：

汪睿

史清明

机构：

[1] 安徽省肺科医院肿瘤科

来源：

安徽卫生职业技术学院学报 | 2009年 / 8卷 / 06期

关键词：

肝纤维化; 肝星状细胞; 枯否细胞; 细胞因子;

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

肝纤维化(HF)是诸多慢性肝病共同的病理过程,也是各种慢性肝病向肝硬化转归的中转站。肝星状细胞(HSC)是细胞外基质(ECM)的主要来源,在肝纤维化形成中起关键性作用。枯否细胞(KC)是肝脏内重要的非实质细胞,KC通过分泌一系列细胞因子参与HSC的活化。参与肝纤维化的发生与发展。在肝纤维化的恢复阶段,KC可抑制HSC活性,促进其凋亡从而发挥抗纤维化作用。因此,深入研究Kupffer细胞与HSC的Cross-talk在肝纤维化的发生与发展中的作用和机制,对于临床工作中防治肝脏损伤,提高患者生存率具有实际意义。

引用

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页码：39 / 40

页数：2

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