糖皮质激素诱导骨质疏松的细胞及分子学机制

被引:12
作者
刘素彩
李恩
机构
[1] 河北医科大学生物化学教研室!河北石家庄
关键词
糖皮质激素; 骨细胞,骨质疏松; 骨代谢;
D O I
暂无
中图分类号
R58 [内分泌腺疾病及代谢病];
学科分类号
1002 ; 100201 ;
摘要
长期大剂量使用糖皮质激素会诱发骨质疏松 ,其机制为糖皮质激素抑制成骨细胞的增殖及分化 ,促进成骨细胞的凋亡 ,并降低其功能 ,使骨形成延迟并减少。它可抑制破骨细胞的产生 ,但是否影响破骨细胞的活性则尚不清楚 ;此外 ,它也可促进破骨细胞凋亡。
引用
收藏
页码:11 / 13
页数:3
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