白细胞介素1受体相关激酶M在脓毒症免疫麻痹中的作用

被引：8

作者：

蒋政宇

卞金俊

邓小明

机构：

[1] 上海,海军军医大学附属长海医院麻醉学部

来源：

国际麻醉学与复苏杂志 | 2018年 / 39卷 / 02期

关键词：

白细胞介素1受体相关激酶M; 脓毒症; 免疫麻痹;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

背景白细胞介素1受体相关激酶M(interleukin 1 receptor-associated kinase M, IRAK-M)是Toll样受体(toll-like receptor, TLR)信号通路中重要的负向调控因子, 可通过抑制NF-κB炎症信号通路来限制过度的炎症反应。目的通过研究IRAK-M限制炎症反应的相关机制, 可以为脓毒症免疫麻痹的具体机制提供新的思路。内容综述近年来关于IRAK-M对TLR通路中转化生长因子-β激活激酶1(transforming growth factor-β activated kinase-1, TAK1)依赖性与促分裂原活化蛋白激酶/细胞外信号调节激酶-激酶3(mitogen-activated protein kinase/extracellular signal-regulated kinase-kinase 3, MEKK3)依赖性的通路, 并综述IRAK-M被众多TLR分子、细胞因子调控表达及其本身的表观遗传调控方面的机制。趋向现有研究初步阐述了IRAK-M可能通过抑制炎症反应通路而加重脓毒症免疫麻痹的相关病理机制, 并提示IRAK-M可能作为脓毒症患者免疫状态和免疫调节治疗的靶点。

引用

共 36 条

[1]

A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages..[J].Maria C Maldifassi;Gema Atienza;Francisco Arnalich;Eduardo López-Collazo;Jose L Cedillo;Carolina Martín-Sánchez;Anna Bordas;Jaime Renart;Carmen Montiel.PLoS ONE.2017, 9

[2]

Activator protein 1 promotes the transcriptional activation of IRAK-M.[J].Peipei Jin;Lulong Bo;Yongjian Liu;Wenbin Lu;Shengwei Lin;Jinjun Bian;Xiaoming Deng.Biomedicine & Pharmacotherapy.2016,

[3]

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression.[J].Naeem K. Patil;Julia K. Bohannon;Edward R. Sherwood.Pharmacological Research.2016,

[4]

IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3 [J].

Kesselring, Rebecca ;

Glaesner, Joachim ;

Hiergeist, Andreas ;

Naschberger, Elisabeth ;

Neumann, Helmut ;

Brunner, Stefan M. ;

Wege, Anja K. ;

Seebauer, Caroline ;

Koehl, Gudrun ;

Merkl, Susanne ;

Croner, Roland S. ;

Hackl, Christina ;

Stuerzl, Michael ;

Neurath, Markus F. ;

Gessner, Andre ;

Schlitt, Hans-Juergen ;

Geissler, Edward K. ;

Fichtner-Feigl, Stefan .

CANCER CELL, 2016, 29 (05) :684-696

[5]

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M [J].

Miyata, Masanori ;

Lee, Ji-Yun ;

Susuki-Miyata, Seiko ;

Wang, Wenzhuo Y. ;

Xu, Haidong ;

Kai, Hirofumi ;

Kobayashi, Koichi S. ;

Flavell, Richard A. ;

Li, Jian-Dong .

NATURE COMMUNICATIONS, 2015, 6

[6]

The structure function of the death domain of human IRAK-M..[J].Du Jiangfeng;Nicolaes Gerry Af;Kruijswijk Danielle;Versloot Miranda;van der Poll Tom;van 't Veer Cornelis.Cell communication and signaling : CCS.2014, 1

[7]

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series [J].

Delsing, Corine E. ;

Gresnigt, Mark S. ;

Leentjens, Jenneke ;

Preijers, Frank ;

Frager, Florence Allantaz ;

Kox, Matthijs ;

Monneret, Guillaume ;

Venet, Fabienne ;

Bleeker-Rovers, Chantal P. ;

van de Veerdonk, Frank L. ;

Pickkers, Peter ;

Pachot, Alexandre ;

Kullberg, Bart Jan ;

Netea, Mihai G. .

BMC INFECTIOUS DISEASES, 2014, 14

[8]

Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages [J].

Sung, Nak-Yun ;

Yang, Mi-So ;

Song, Du-Sub ;

Kim, Jae-Kyung ;

Park, Jong-Heum ;

Song, Beom-Seok ;

Park, Sang-Hyun ;

Lee, Ju-Woon ;

Park, Hyun-Jin ;

Kim, Jae-Hun ;

Byun, Eui-Baek ;

Byun, Eui-Hong .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 438 (01) :122-128

[9]

Sepsis definitions: time for change [J].

Vincent, Jean-Louis ;

Opal, Steven M. ;

Marshall, John C. ;

Tracey, Kevin J. .

LANCET, 2013, 381 (9868) :774-775

[10]

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production [J].

Zhou, Hao ;

Yu, Minjia ;

Fukuda, Koichi ;

Im, Jinteak ;

Yao, Peng ;

Cui, Wei ;

Bulek, Katarzyna ;

Zepp, Jarod ;

Wan, Youzhong ;

Kim, Tae Whan ;

Yin, Weiguo ;

Ma, Victoria ;

Thomas, James ;

Gu, Jun ;

Wang, Jian-an ;

DiCorleto, Paul E. ;

Fox, Paul L. ;

Qin, Jun ;

Li, Xiaoxia .

EMBO JOURNAL, 2013, 32 (04) :583-596

← 1 2 3 4 →