基质金属蛋白酶-9与脑缺血血脑屏障损伤的关系

被引:23
作者
毛玲
查运红
梅元武
机构
[1] 华中科技大学同济医学院附属协和医院神经内科
关键词
基质金属蛋白酶-9; 血脑屏障; 脑缺血; 脑水肿;
D O I
10.16636/j.cnki.jinn.2006.01.028
中图分类号
R741 [神经病学];
学科分类号
1002 ;
摘要
基质金属蛋白酶9(MMP9)是一种基质金属蛋白酶,脑缺血时可以通过降解基底膜及紧密连接破坏血脑屏障,从而导致脑缺血后继发性脑水肿和脑出血。了解MMP9及其与脑缺血性损伤的关系、脑缺血时其在中枢神经系统的变化、及其在脑缺血时如何作用于血脑屏障,无疑为预防和治疗脑缺血后的并发症指出了新的方向。
引用
收藏
页码:96 / 98
页数:3
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