NOD1和NOD2介导的信号通路及其抗病毒免疫应答研究进展

被引：6

作者：

陈明发 ^{[1
]}

吴珺 ^{[2
]}

杨东亮 ^{[2
]}

机构：

[1] 南昌大学第二附属医院感染科

[2] 华中科技大学同济医学院附属协和医院感染科

来源：

国际免疫学杂志 | 2013年 / 36卷 / 03期

关键词：

NOD1蛋白; NOD2蛋白; 信号通路; 固有免疫;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

NOD1和NOD 2蛋白为胞浆内模式识别受体,其识别进入胞内的细菌胞壁及其降解产物,介导NF-κB和MAPKs信号途径,产生相关效应分子,介导了抗病原微生物免疫应答。近年来的最新研究发现,NOD1受体还通过ISGF3信号途径诱导产生1型干扰素,NOD2受体能识别ssRNA和病毒基因组ssRNA,通过MAVs信号途径激活IRF3,诱导产生1型干扰素,1型干扰素又可正向调控NOD1和NOD2功能性表达。NOD1和NOD2通过介导新的信号途径诱导产生大量的1型干扰素,并参与抗病毒固有免疫应答。因而,对NOD1和NOD2介导的抗病毒免疫应答新认识,将为防治病毒感染性疾病的研究提供新策略。

引用

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