人脐带间充质干细胞的生物学性质研究进展

被引：17

作者：

范存刚

周景儒

张庆俊

机构：

[1] 北京大学人民医院神经外科

来源：

基础医学与临床 | 2010年 / 30卷 / 02期

关键词：

脐带; 间充质干细胞; 分化;

D O I：

10.16352/j.issn.1001-6325.2010.02.009

中图分类号：

R329 [人体组织学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

人脐带中富含间充质干细胞(MSCs)。这些细胞能表达多种间充质干细胞标志物及多种干细胞相关基因,能分化为3个胚层衍生的多种成熟细胞,合成多种营养因子和细胞因子,支持造血干细胞等细胞的增殖和功能,并具有低免疫原性。

引用

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页码：215 / 218

页数：4

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共 6 条

[1]

Mesenchymal stem cells from the Wharton's jelly of umbilical cord segments provide stromal support for the maintenance of cord blood hematopoietic stem cells during long-term ex vivo culture [J].

Bakhshi, Tiki ;

Zabriskie, Ryan C. ;

Bodie, Shamanique ;

Kidd, Shannon ;

Ramin, Susan ;

Paganessi, Laura A. ;

Gregory, Stephanie A. ;

Fung, Henry C. ;

Christopherson, Kent W., III .

TRANSFUSION, 2008, 48 (12) :2638-2644

[2]

Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation [J].

Pereira, Winston Costa ;

Khushnooma, Italia ;

Madkaikar, Manisha ;

Ghosh, K. .

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2008, 2 (07) :394-399

[3]

Fetal mesenchymal stem cells derived from human umbilical cord sustain primitive characteristics during extensive expansion [J].

Jo, Chris H. ;

Kim, Ok-Su ;

Park, Eun-Young ;

Kim, Byoung Jae ;

Lee, Ji-Ho ;

Kang, Seung-Baik ;

Lee, Jae Hyup ;

Han, Hyuk Soo ;

Rhee, Seung Hwan ;

Yoon, Kang-Sup .

CELL AND TISSUE RESEARCH, 2008, 334 (03) :423-433

[4]

Umbilical cord mesenchymal stem cells increase expansion of cord blood natural killer cells [J].

Boissel, Laurent ;

Tuncer, Hande H. ;

Betancur, Monica ;

Wolfberg, Adam ;

Klingemann, Hans .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (09) :1031-1038

[5]

Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells [J].

Campard, David ;

Lysy, Philippe A. ;

Najimi, Mustapha ;

Sokal, E-Fienne Marc .

GASTROENTEROLOGY, 2008, 134 (03) :833-848

[6]

Transformation of human umbilical mesenchymal cells into neurons in vitro [J].

Fu, YS ;

Shih, YT ;

Cheng, YC ;

Min, MY .

JOURNAL OF BIOMEDICAL SCIENCE, 2004, 11 (05) :652-660