肝纤维化相关细胞因子和信号通路研究进展

被引：24

作者：

卢玮

刘学恩

庄辉

机构：

[1] 北京大学医学部基础医学院病原生物学系和感染病中心

来源：

中国病毒病杂志 | 2016年 / 6卷 / 05期

关键词：

肝纤维化; 肝星状细胞; 细胞因子; 信号通路;

D O I：

10.16505/j.2095-0136.2016.05.013

中图分类号：

R575.2 [肝硬变]; R446.11 [血液学检验];

学科分类号：

100201 [内科学]; 100208 [临床检验诊断学];

摘要：

肝纤维化是由多种病因引起的肝脏疾病普遍的病理过程,是肝脏细胞外基质(extracellular matrix,ECM)生成与降解失衡,进而导致肝脏内纤维结缔组织异常沉积的结果。肝星状细胞(hepatic stellate cell,HSC)的激活是肝纤维化的中心事件,多种细胞因子参与这一过程,当促纤维化因子与抗纤维化因子的作用发生失衡,而最终促纤维化因子占据优势导致肝纤维化发生。本文简要综述肝纤维化相关的重要细胞因子及发生作用的信号通路。

引用

收藏

页码：385 / 390

页数：6

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