白介素-33在心血管系统中的研究进展

被引:1
作者
范天全
张运卫
杨惠建
王治国
机构
[1] 总参谋部北京塔院干休所
关键词
白介素-33; 心血管系统; 研究进展;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
100201 [内科学];
摘要
<正>冠状动脉粥样硬化是脉管系统常见的慢性疾病,以血管壁慢性炎症为特征。小鼠冠状动脉粥样硬化模型中发现Th1细胞是冠状动脉粥样硬化发病中关键的病理因素。而动脉粥样硬化斑块中的T细胞主要是CD4+亚型,主要产生Th1亚型细胞因子,如IFN-γ。相反,Th2细胞可以产生抗动脉
引用
收藏
页码:149 / 152
页数:4
相关论文
共 6 条
[1]
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines [J].
Schmitz, J ;
Owyang, A ;
Oldham, E ;
Song, YL ;
Murphy, E ;
McClanahan, TK ;
Zurawski, G ;
Moshrefi, M ;
Qin, JZ ;
Li, XX ;
Gorman, DM ;
Bazan, JF ;
Kastelein, RA .
IMMUNITY, 2005, 23 (05) :479-490
[2]
Antibodies to oxidized LDL in atherosclerosis development—clinical and animal studies.[J].Johannes Hulthe.Clinica Chimica Acta.2004, 1
[3]
The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice [J].
Davenport, P ;
Tipping, PG .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (03) :1117-1125
[4]
Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy [J].
Marian, AJ .
LANCET, 2000, 355 (9197) :58-60
[5]
Cytokine secretion profiles of cloned T cells from human aortic atherosclerotic plaques [J].
De Boer, OJ ;
Van der Wal, AC ;
Verhagen, CE ;
Becker, AE .
JOURNAL OF PATHOLOGY, 1999, 188 (02) :174-179
[6]
DIVERGENT EFFECTS OF LPS ON EXPRESSION OF IL-1 RECEPTOR FAMILY MEMBERS IN MONONUCLEAR PHAGOCYTES IN VITRO AND IN VIVO.[J].Simona Saccani;Nadia Polentarutti;Giselle Penton-Rol;John E. Sims;Alberto Mantovani.Cytokine.1998, 10