脑外伤患者血清炎症细胞因子与颅内压关系的研究

被引：13

作者：

蒋文庆

卞晓星

陈红春

魏文峰

金鹏

机构：

[1] 江苏省常州市武进人民医院神经外科

来源：

重庆医学 | 2017年 / 46卷 / 08期

关键词：

脑损伤; 颅内压; 炎症细胞因子; 神经炎症; 生物标记物;

D O I：

暂无

中图分类号：

R651.15 [];

学科分类号：

摘要：

目的研究重型脑外伤手术患者血清炎症细胞因子与颅内压(ICP)之间的关系。方法 32例重型脑外伤患者均于术中放置ICP探头,术前及术后每12小时采集血清并测定白细胞介素1β(IL-1β)、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α),并比较各炎症因子与患者预后的关系。记录每小时ICP值,以12h为周期,20mm Hg为基线,将该时间段超过20mm Hg的ICP差值累加,得到ICP的时间累积值(PTD-ICP20),将该值分别与该12h周期前(Pre)和后(Post)各炎症因子行直线回归分析。结果血清IL-1β、IL-8及TNF-α均与患者预后显著相关(P<0.05)。本组患者的PTD-ICP20均值为(42.9±60.2)mm Hg/h。Pre-IL-8(r=0.554,P<0.05)、Pre-TNF-α、Post-IL-8及Post-TNF-α均与PTD-ICP20呈正相关(r=0.554、0.597、0.629、0.538,P<0.05)。结论血清IL-8及TNF-α可作为监测脑外伤患者ICP的生物标记物,对指导脑外伤诊治,改善患者预后有重要价值。

引用

页码：1060 / 1062

页数：3

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