柴胡皂苷a抗抑郁作用机制的研究进展

被引：106

作者：

刘敏

孙亚南

于春月

王琪

魏太明

机构：

[1] 哈尔滨医科大学大庆校区药学院

来源：

现代药物与临床 | 2019年 / 34卷 / 03期

关键词：

柴胡皂苷a; 抑郁症; 神经炎症; 神经递质; 脑源性神经营养因子;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

抑郁症是一种常见的精神类疾病,发病率高、致死率高,严重影响人类身体健康。柴胡具有疏肝解郁之功效,临床上多用其复方制剂治疗抑郁症。近年来发现,柴胡中的柴胡皂苷a具有潜在的抗抑郁作用,能通过调节炎症因子及相关通路,增强神经营养因子表达,改善神经递质水平及神经元细胞凋亡,下调下丘脑–垂体–肾上腺(HPA)轴功能发挥抗抑郁作用。主要对柴胡皂苷a的抗抑郁作用机制进行综述,便于为药物研发和抑郁症的研究提供思路。

引用

页码：867 / 871

页数：5

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