雄激素致高胰岛素与高雄激素性无排卵大鼠模型

被引：57

作者：

俞瑾

杨淑萍

张月萍

魏美娟

归绥琪

机构：

[1] 上海医科大学妇产科医院中医科

来源：

生殖医学杂志 | 1993年 / 04期

关键词：

雄激素; 胰岛素; 不育; 动物,实验;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

给9日龄 SD 雌性大鼠注射丙酸睾丸酮造成雄激素致不孕大鼠（ASR）,分别观察卵巢形态、血液及组织匀浆激素含量、糖耐量和血胰岛素水平以及卵泡膜和卵巢间质细胞在体外不同刺激状态下（空白、加胰岛素、加 hCG、加胰岛素+hCG）的 T 含量。结果发现:（1）卵巢体积缩小,呈多囊性改变,无黄体;（2）垂体 LH 含量比对照组降低（P<0.01）,肾上腺及卵巢中 T、E2 含量明显升高（分别为P<0.05及P<0.01）;（3）糖耐量下降,胰岛素水平显著升高（分别为 P<0.01及 P<0.05）;（4）卵泡膜和卵巢间质细胞体外培养 T 含量明显高于对照组（P<0.001）,在 hCG 协同作用下胰岛素可使 ASR 及正常大鼠卵巢 T 含量明显增加（P<0.01）。提示雄激素致不孕大鼠可作为高胰岛素和高雄激素性无排卵的动物模型。

引用

页码：215 / 219

页数：5

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